Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors

IntroductionImmune-checkpoint inhibitors are effective in various advanced cancers.Type 1 diabetes mellitus induced by them (ICI-T1DM) is a serious complication requiring prompt insulin treatment, but the immunological mechanism behind it is unclear.MethodsWe examined amino acid polymorphisms in we care vitamin a and d ointment human histocompatibi

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Design study of a Martian rotor blade using a triangular airfoil

The Martian atmosphere is characterized by a low density and low speed of sound, which result in w insta saree the low Reynolds number compressible flows.In this regime, conventional airfoils perform poorly due to the boundary layer separation and the formation of shack wave.The current paper investigates the hovering performance and the structure

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